Differentiation of ribonucleic acids by inhibition of streptococcal deoxyribonuclease.
نویسنده
چکیده
It has been shown (Bernheimer & Ruffier, 1951 ) that physical disruption of streptococci belonging to Lancefield groups A, B, C and D results in the liberation of a substance which partially inhibits the depolymerizing action of group A streptococcal deoxyribonuclease. One of the striking characteristics of the inhibitory substance is its specificity, for although it inhibits the deoxyribonuclease produced by group A streptococci, it fails to inhibit deoxyribonucleases prepared from pancreas, barley, yeast or even those of streptococci belonging to groups B and C. The inhibitor has been identified as streptococcal ribonucleic acid. There arises the question of whether the inhibition of group A streptococcal deoxyribonuclease is an effect associated specifically with ribonucleic acid of streptococcal origin or whether ribonucleic acids, regardless of source, will inhibit the enzyme. The only information bearing on this point is the result of an experiment in which yeast nucleic acid was found not to inhibit (Bernheimer & Ruffier, 1951). The present study is concerned with the capacity of ribonucleic acids, prepared from diverse sources, to inhibit the streptococcal enzyme.
منابع مشابه
The deoxyribo-nucleases of Escherichia coli. III. Studies on the nature of the inhibition of endonuclease by ribonucleic acid.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 53 1 شماره
صفحات -
تاریخ انتشار 1953